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While genetics, environment, and toxic exposures are frequently discussed, nutritional status is often overlooked as a fundamental contributor to neurodevelopmental outcomes

In addition, we propose that FIN, triggered by HIV-1 infection and long-term cART use, may be counteracted by an epigenetic system comprised of bromodomain protein 4 (BRD4) and microRNA-29 (miR 29) that inhibits ferritinophagy by several mechanisms, including direct antiviral action, lysosomal suppression, SLC7A11 activation, and iron regulatory protein-2 (IRP-2) inhibition